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Combined Analysis of Single Cell and Spatial Transcriptome Reveals Regulation of Anti-human TREM2 Agonist Monoclonal Antibody on the Functional Status of Microglia and Identification of Key Subsets and Biomarkers
Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident…
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Phytochemicals as a Promising Approach to Rheumatoid Arthritis: Current Perspectives
Announcing a new article publication for BIO Integration journal. In recent years, phytochemicals and medicinal plants have increasingly been used to treat autoimmune diseases, such as rheumatoid arthritis (RA). RA,…
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Albinism-Associated Genes and Non-Skin Cancer: Bioinformatics Analysis of Relevant miRNAs
Announcing a new article publication for BIO Integration journal that reports potential molecular links between albinism-associated genes and several non-skin cancers. While albinism is primarily connected to pigmentation changes and…
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Digestive System Toxicities of Immune Checkpoint Inhibitors: Mechanisms and Clinical Implications
Announcing a new article publication for BIO Integration journal. Immune checkpoint inhibitors (ICIs) have achieved remarkable efficacy in treating malignancies but may simultaneously induce immune-related adverse events (irAEs), among which…
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Differentiating Hepatic Perivascular Epithelioid Cell Tumor from Hepatocellular Carcinoma without High-Risk Factors using Contrast-Enhanced Ultrasound
Announcing a new article publication for BIO Integration journal. Hepatic perivascular epithelioid cell tumor (PEComa) is a rare tumor with malignant potential that is frequently misdiagnosed as hepatocellular carcinoma (HCC),…
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Understanding Vascular Toxicity of Indigo Naturalis in Anti-Inflammatory Applications: Mendelian Randomization and Co-localization Study
Announcing a new article publication for BIO Integration journal. Indigo naturalis (IN), a traditional Chinese herbal medicine, shows promising potential for treating autoimmune inflammatory diseases. However, its clinical translation and…
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Ultrasound-Trained Artificial Intelligence for Postmenopausal Adnexal Lesion Characterization: A Multicenter Diagnostic Accuracy Study
Announcing a new publication in BIO Integration journal. The purpose of this work was to establish and assess deep learning (DL) models based on ultrasound images for discriminating between benign…
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A Promising Path Forward in Obesity Pharmacotherapy: Ecnoglutide and the Evolution of GLP-1R Agonist Design
Announcing a new article publication for BIO Integration journal. This article reviews robust evidence from a large, multicenter, randomized, placebo-controlled study in Chinese adults with overweight or obesity, demonstrating dose-dependent…