Low-intensity Pulsed Ultrasound Enhances NK Cell Adoptive Therapy by Modulating the Wnt/β-catenin Signaling Pathway

Announcing a new article publication for BIO Integration journal. Natural killer cell adoptive therapy is a novel immunotherapy strategy for the treatment of multiple refractory tumors, including ovarian cancer.

However, natural killer cells’ anti-tumor effectiveness is limited by their viability and cytotoxicity. This study suggests that ultrasound irradiation improves the therapeutic effects of natural killer cells on ovarian cancer through an unclear mechanism. The Wnt/β-catenin signaling pathway is a complex protein network system associated with the maturation and function of natural killer cells.

To reveal the precise mechanism underlying the effects of ultrasound on natural killer cells, the expression of Wnt/β-catenin signaling pathway proteins were measured before and after ultrasound irradiation. The expression of therapeutic factors secreted by natural killer cells increased after ultrasound irradiation. Therefore, this study provides an additional strategy for optimizing the therapeutic efficiency of natural killer cells.

Read more: https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0036

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ISSN 2712-0074

eISSN 2712-0082 Renjie Feng, Ao Gu and Gökhan Zengin et al. Low-intensity Pulsed Ultrasound Enhances NK Cell Adoptive Therapy by Modulating the Wnt/β-catenin Signaling Pathway. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0036