A Strategy for Antigen Amplification via Nanozyme-Catalyzed Proximity Labeling

Announcing a new article publication for BIO Integration journal. This article discusses a new therapeutic strategy called PATCH (Proximity Antigen Tagging of Cytotoxic Haptens), which adapts proximity labeling (PL)—traditionally a proteomics tool—into a cancer treatment approach. Using a red-light and ultrasound-activated nanozyme, PATCH creates high-density synthetic antigen clusters on tumor cell surfaces. These clusters enhance receptor activation, stimulate T cell engagement, and lead to strong anti-tumor immune responses, including tumor eradication, abscopal effects, and durable immune memory in mouse models. Unlike conventional PL systems, PATCH avoids toxic cofactors and limited light penetration, making it more clinically feasible for solid tumors. While promising, challenges remain in pharmacokinetics, large-animal validation, manufacturing scalability, and long-term biocompatibility. Overall, PATCH represents a shift from engineering immune receptors to reshaping the antigenic environment, opening new opportunities for oncology, immunotherapy, and broader biomedical applications

Read full article at https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-1003

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ISSN 2712-0074

eISSN 2712-0082 Yinghui Men, Ke Shao and Yingcheng Wu. A Strategy for Antigen Amplification via Nanozyme-Catalyzed Proximity Labeling. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-1003