Asymmetric Cell Division as a Mechanistic Contributor to Cancer with a Focus on Glioblastoma
Announcing a new article publication for BIO Integration journal. Asymmetric cell division (ACD) has a crucial role in normal cellular differentiation and tissue homeostasis. The mechanisms underlying ACD are highly intricate and involve coordinated molecular and cellular processes. Dysregulation of ACD has been implicated in various human cancers by contributing to malignant tumor initiation, progression, metastasis, and treatment resistance. Although numerous studies have explored the relationship between ACD and cancer, many questions remain unanswered. This literature review aimed to evaluate the potential biological significance of ACD in cancer with a focus on the diagnostic and prognostic relevance to glioblastoma. A comprehensive PubMed search was conducted from 2008 to the present using keywords, such as “asymmetric cell division”, “cancer”, “glioblastoma”, and “tumorigenesis”. The selected articles were analyzed to assess ACD-related data and the clinical correlations. Special emphasis was placed on glioblastomas, an aggressive brain tumor with limited improvement in patient survival over recent years. This review underscores the crucial role of ACD in normal tissue homeostasis and ACD dysregulation in cancer initiation, progression, therapeutic resistance, and metastatic potential. Understanding how ACD contributes to cancer heterogeneity may provide insights into innovative strategies for tumor detection, monitoring, and treatment. Future research into the molecular mechanisms governing ACD could facilitate the development of novel glioblastoma therapies aimed at restoring or modulating ACD processes to improve patient outcomes.
Read full article: https://www.scienceopen.com/hosted-document?doi=10.15212/bioi-2025-0076
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ISSN 2712-0074
eISSN 2712-0082
Rebecca Golin, Genia Bekker and Hengrui Liu. Asymmetric Cell Division as a Mechanistic Contributor to Cancer with a Focus on Glioblastoma. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0076
