WukongBot: A Brain-Spine Interface Proof of Concept Based on Non-Invasive Brain-Computer Interface for Spinal Cord Injury in a Monkey

Announcing a new article publication for BIO Integration journal. Motor dysfunction constitutes a significant global public health burden. In China, greater than 20 million individuals have various forms of paralysis with stroke and spinal cord injury (SCI) being the leading causes. Epidemiologic data indicate that there are approximately 3.74 million existing SCI cases in China with approximately 90,000 new cases reported annually. Restoration of autonomous walking ability remains one of the most pressing rehabilitation goals for paralyzed patients.

In recent years epidural electrical stimulation (EES) has emerged as a promising intervention for functional recovery in SCI. Existing studies have shown that EES can promote the recovery of voluntary motor control in SCI by facilitating motor neuron function and re-establishing functional connections between the brain and spinal cord, thereby restoring autonomous movement.

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ISSN 2712-0074

eISSN 2712-0082 Lifen Mo, Long Chen and Yichang Liao et al. WukongBot: A Brain-Spine Interface Proof of Concept Based on Non-Invasive Brain-Computer Interface for Spinal Cord Injury in a Monkey. BIOI. 2025. Vol. 6(1). DOI: 10.15212/bioi-2025-0171